R1-ICR-5 | RIPK1 PROTAC | Probechem Biochemicals

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Chemical Structure : R1-ICR-5

R1-ICR-5 (RIPK1 PROTAC degrader)

Catalog No.: PC-22429Not For Human Use, Lab Use Only.

R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis

Physicochemical Properties

M.Wt	1007.32
Formula	C54H70N8O7S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	cyclohexyl (5-(2-(12-(((R)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylisothiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecanamido)benzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate

References

1. Mannion J, et al. Immunity. 2024 May 15:S1074-7613(24)00230-9.

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R1-ICR-5 (RIPK1 PROTAC degrader)

Biological Activity

Physicochemical Properties

References

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