Catalog No.: PC-22356Not For Human Use, Lab Use Only.
GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner.
GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner.
GT-653 (0-20 uM) induced KDM5B degradation and H3K4me3 upregulation in 22RV1 cells, significantly degraded the KDM5B with a degradation rate of 68.35 %, does not affect KDM5A or KDM5C with CRBN.
GT-653 induced KDM5B degradation in a ubiquitin proteasome system dependent manner.
GT-653 treatment upregulated interferon (IFN) response genes in prostate cancer.
