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Chemical Structure : GT-653
CAS No.:
Catalog No.: PC-22356Not For Human Use, Lab Use Only.
GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner.
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GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner.
GT-653 (0-20 uM) induced KDM5B degradation and H3K4me3 upregulation in 22RV1 cells, significantly degraded the KDM5B with a degradation rate of 68.35 %, does not affect KDM5A or KDM5C with CRBN.
GT-653 induced KDM5B degradation in a ubiquitin proteasome system dependent manner.
GT-653 treatment upregulated interferon (IFN) response genes in prostate cancer.
| M.Wt | 653.61 | |
| Formula | C32H27N7O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(4-(3-cyano-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl)phenoxy)-N-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethyl)acetamide |
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1. Tian Guan, et al. Eur J Med Chem. 2024 May 10:272:116494.
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