| Cat. No. |
Product Name |
Information |
| PC-38738 |
Degradomer D-1
IRAK3 degarder
|
Degradomer D-1 is a selective proteasomal degrader of IRAK3 with Kd of 100 nM, DC50 of 94 nM, displays no binding affinity against IRAK4 (Ki >10 uM). |
| PC-38718 |
CRBN(BRAF)-24
BRAF V600E PROTAC
|
CRBN(BRAF)-24 is a potent small molecule degrader against oncogenic BRAF V600E protein, potently degrades BRAFV600E in a ubiquitin–proteasome system (UPS)-dependent manner and inhibits the proliferation of BRAFV600E-driven cancer cells. |
| PC-38566 |
STING PROTAC SP23
STING PROTAC
|
SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM. |
| PC-38462 |
dBRD9 dihydrochloride
BRD9 PROTAC
|
dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells. |
| PC-73343 |
YX-2-115
CDK6 inhibitor
|
YX-2-115 is a palbociclib derivative compound with piperazine-linker tail for PROTAC YX-2-107 synthesis, inhibits CDK6 with IC50 of 4.5 nM. |
| PC-73342 |
YX-2-107
CDK6 degrader
|
YX-2-107 is a CRBN-recruiting and specific CDK6-degrading PROTAC with IC50 of 0.69 and 4.4 nM for CDK4 and CDK6 in vitro, selectively degardes CDK6 in Ph+ BV173 ALL cells with a degradation constant of 4 nM. |
| PC-73310 |
CFT-14441
BRD9 BiDAC degrader
|
CFT-14441 is a potent and selective BRD9 BiDAC degrader with DC50 of 39 nM (2h), high selectivity over BRD4 abd BRD7. |
| PC-73289 |
BSJ-04-132
CDK4 degrader
|
BSJ-04-132 is a selective CDK4 degrader (PROTAC), does not induce IKZF1/3 degradation. |
| PC-73288 |
BSJ-03-204
CDK4/6 degrader
|
BSJ-03-204 is a dual and selective degrader (PROTAC) of CDK 4 and 6, does not induce IKZF1/3 degradation. |
| PC-73165 |
ERD-308
Estrogen receptor PROTAC
|
ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively. |
| PC-73109 |
SD-36
STAT3 degrader
|
SD-36 (STAT3 degrader SD-36) is a potent, selective STAT3 degrader (PROTAC), potently induces the degradation of STAT3 protein in vitro and in vivo. |
| PC-73098 |
YKL-06-101
CDK8 degarder
|
YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM). |
