Cat. No. |
Product Name |
Information |
PC-63465 |
JH-XI-10-02
CDK8 PROTAC
|
JH-XI-10-02 is a CDK8 PROTAC based on the CDK8 inhibitor JH-VIII-49, induces partial degradation of CDK8 in Jurkat cells with IC50 of 159 nM. |
PC-63217 |
dTRIM24
TRIM24 PROTAC
|
dTRIM24 is a potent and selective, bifunctional PROTAC degrader of TRIM24 with IC50 of 337.7 nM in TRIM24 ligand displacement assay. |
PC-62321 |
dBET1
BET PROTAC
|
dBET1 is a proteolysis-targeting chimera (PROTAC) molecule that appendes a competitive antagonist of BET bromodomain (JQ1) to a phthalimide moiety to hijack the cereblon E3 ubiquitin ligase complex. |
PC-61699 |
dBET6
BET PROTAC
|
dBET6 is a highly potent, cell-permeable, optimized chemical degrader of BET bromodomain BRD4 with IC50 of 14 nM. |
PC-60931 |
BETd-246
BET PROTAC
|
BETd-246 (BETd246) is a potent, second-generation BET protein PROTAC degrader that exhibits superior selectivity, potency and antitumor activity. |
PC-60484 |
TBK1 PROTAC 1
TBK1 PROTAC
|
TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε. |
PC-60330 |
THAL-SNS-032
CDK9 PROTAC
|
THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). |
PC-70206 |
SNIPER(AR)-51
Androgen Receptor degrader
|
SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker. |
PC-60234 |
CCT-367766
Pirin degrader
|
CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.. |
PC-60127 |
CM11
VHL degrader
|
CM11 is a homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce VHL self-degradation. |
PC-60126 |
dBRD9
BRD9 PROTAC
|
dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells. |
PC-60125 |
CC-885
GSPT1 PROTAC
|
CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1. |