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Cat. No. Product Name Information
PC-63465

JH-XI-10-02

CDK8 PROTAC

JH-XI-10-02 is a CDK8 PROTAC based on the CDK8 inhibitor JH-VIII-49, induces partial degradation of CDK8 in Jurkat cells with IC50 of 159 nM.
PC-63217

dTRIM24

TRIM24 PROTAC

dTRIM24 is a potent and selective, bifunctional PROTAC degrader of TRIM24 with IC50 of 337.7 nM in TRIM24 ligand displacement assay.
PC-62321

dBET1

BET PROTAC

dBET1 is a proteolysis-targeting chimera (PROTAC) molecule that appendes a competitive antagonist of BET bromodomain (JQ1) to a phthalimide moiety to hijack the cereblon E3 ubiquitin ligase complex.
PC-61699

dBET6

BET PROTAC

dBET6 is a highly potent, cell-permeable, optimized chemical degrader of BET bromodomain BRD4 with IC50 of 14 nM.
PC-60931

BETd-246

BET PROTAC

BETd-246 (BETd246) is a potent, second-generation BET protein PROTAC degrader that exhibits superior selectivity, potency and antitumor activity.
PC-60484

TBK1 PROTAC 1

TBK1 PROTAC

TBK1 PROTAC 1 (Compound 3i) is a potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.
PC-60330

THAL-SNS-032

CDK9 PROTAC

THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).
PC-70206

SNIPER(AR)-51

Androgen Receptor degrader

SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker.
PC-60234

CCT-367766

Pirin degrader

CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells..
PC-60127

CM11

VHL degrader

CM11 is a homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce VHL self-degradation.
PC-60126

dBRD9

BRD9 PROTAC

dBRD9 is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.
PC-60125

CC-885

GSPT1 PROTAC

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1.

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