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SJPYT-195

Chemical Structure : SJPYT-195

CAS No.:

SJPYT-195 (SJPYT195)

Catalog No.: PC-49310Not For Human Use, Lab Use Only.

SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligandof the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligand of the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein.

Physicochemical Properties

M.Wt 666.691
Formula C35H34N6O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-(tert-butyl)-5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide

References

1. Andrew D Huber, et al. ACS Med Chem Lett. 2022 Jul 15;13(8):1311-1320.

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