SJPYT-195 | GSPT1 PROTAC | Probechem Biochemicals

Chemical Structure : SJPYT-195

SJPYT-195 (SJPYT195)

Catalog No.: PC-49310Not For Human Use, Lab Use Only.

SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligandof the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein.

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Biological Activity

SJPYT-195 is a small molecule glue degrader (PROTAC) of the translation termination factor GSPT1, consists of SPA70 derivative to ligand of the E3 substrate receptor cereblon (CRBN), causes subsequent reduction of PXR protein.

Physicochemical Properties

M.Wt	666.691
Formula	C35H34N6O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(tert-butyl)-5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide

References

1. Andrew D Huber, et al. ACS Med Chem Lett. 2022 Jul 15;13(8):1311-1320.

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SJPYT-195 (SJPYT195)

Biological Activity

Physicochemical Properties

References

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