SJ988497 | JAKs PROTAC | Probechem Biochemicals

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Chemical Structure : SJ988497

Catalog No.: PC-49143Not For Human Use, Lab Use Only.

SJ988497 is a highly potent JAKs degarder proteolysis-targeting chimera (PROTAC), potently kills CRLF2r ALL cell lines (MHH-CALL-4, IC50=0.4 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SJ988497 is a highly potent JAKs degarder proteolysis-targeting chimera (PROTAC), potently kills CRLF2r ALL cell lines (MHH-CALL-4, IC50=0.4 nM).

M.Wt	688.749
Formula	C36H36N10O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)-4-((4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)benzamide

1. Yunchao Chang, et al. Blood. 2021 Dec 9;138(23):2313-2326.