| Cat. No. |
Product Name |
Information |
| PC-21717 |
Chk1 PROTAC-2
Chk1 PROTAC
|
Chk1 PROTAC-2 is a potent Chk1 degrader with DC50 of 1.33 µM in A375 cells. |
| PC-21708 |
PROTAC dCE-1
CBP/EP300 degrader
|
PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells. |
| PC-21652 |
DAS-5-oCRBN
c-Src PROTAC
|
DAS-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 3 nM, without effect on Bcr-Abl. |
| PC-21641 |
DBt-10
DCAF1-BTK-PROTAC
|
DBt-10 is a potent BTK-specific DCAF1 PROTAC with TR-FRET IC50 of 136 nM, potently degrades BTK with DC50 of 137 nM in TMD8 BTK-GFP/mCherry cell-based assays. |
| PC-21424 |
XY-07-35
HDAC6 PROTAC
|
XY-07-35 is a potent, selective HDAC6 proteolysis targeting chimera (PROTAC) degrader with IC50 of 48.5 nM. |
| PC-21127 |
TD-802
AR PROTAC
|
TD-802 is potent, cereblon-mediated androgen receptor PROTAC degrader, effectively inducs AR protein degradation with DC50 of 12.5 nM and Emax 93% in LNCaP prostate cancer cells. |
| PC-21126 |
ARD-2128
AR PROTAC
|
ARD-2128 is a potent, orally active PROTAC androgen receptor (AR) degrader with DC50 of 0.28 nM in CcaP cell line. |
| PC-21125 |
ARD-2585
AR PROTAC
|
ARD-2585 is a potent and orally bioavailable PROTAC androgen receptor (AR) degrader with DC50 of 0.04 nM, Dmax=99% in VCaP cell line. |
| PC-21124 |
MTX-23
AR PROTAC
|
MTX-23 is a proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) splice variant-7 (AR-V7) and AR-full length (AR-FL) with DC50 of 0.37 and 2 uM, respectively. |
| PC-21068 |
JH-XII-03-02
LRRK2 PROTAC
|
JH-XII-03-02 is a highly potent, selective PROTAC degrader of LRRK2 with IC50 of 1 nM against both wt LRRK2 and LRRK2 G2019S. |
| PC-21045 |
KYH1872
PROTAC
|
KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker. |
| PC-21044 |
DB0614
PROTAC
|
DB0614 is a CRBN-based PROTAC, induces the degradation of NEK9, FAK, CDK4, CDK6, and WEE1 in cells. |
