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Chemical Structure : XL01126
Catalog No.: PC-49282Not For Human Use, Lab Use Only.
XL01126 (XL 01126) is a fast and potent degrader of LRRK2 in multiple cell lines with DC50 values of 15-72 nM, Dmax values ranging from 82 to 90%, and degradation half-lives spanning from 0.6 to 2.4 h.
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XL01126 (XL 01126) is a fast and potent degrader of LRRK2 in multiple cell lines with DC50 values of 15-72 nM, Dmax values ranging from 82 to 90%, and degradation half-lives spanning from 0.6 to 2.4 h.
XL01126 exhibits high cell permeability and forms a positively cooperative ternary complex with VHL and LRRK2 (α = 5.7), which compensates for a substantial loss of binary binding affinities to VHL and LRRK2.
XL01126 is orally bioavailable (F = 15%) and can penetrate the blood-brain barrier after either oral or parenteral dosing in mice.
XL01126 is a suitable degrader probe to study the noncatalytic and scaffolding functions of LRRK2 in vitro and in vivo.
| M.Wt | 1019.694 | |
| Formula | C50H64ClFN10O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu X, et al. J Am Chem Soc. 2022 Aug 25. doi: 10.1021/jacs.2c05499.
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