Catalog No.: PC-49282Not For Human Use, Lab Use Only.
XL01126 (XL 01126) is a fast and potent degrader of LRRK2 in multiple cell lines with DC50 values of 15-72 nM, Dmax values ranging from 82 to 90%, and degradation half-lives spanning from 0.6 to 2.4 h.
XL01126 (XL 01126) is a fast and potent degrader of LRRK2 in multiple cell lines with DC50 values of 15-72 nM, Dmax values ranging from 82 to 90%, and degradation half-lives spanning from 0.6 to 2.4 h.
XL01126 exhibits high cell permeability and forms a positively cooperative ternary complex with VHL and LRRK2 (α = 5.7), which compensates for a substantial loss of binary binding affinities to VHL and LRRK2.
XL01126 is orally bioavailable (F = 15%) and can penetrate the blood-brain barrier after either oral or parenteral dosing in mice.
XL01126 is a suitable degrader probe to study the noncatalytic and scaffolding functions of LRRK2 in vitro and in vivo.
