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Chemical Structure : YM281
Catalog No.: PC-49078Not For Human Use, Lab Use Only.
YM281 is potent, EPZ6438-based, von Hippel-Lindau (VHL)-recruiting PROTAC degrader of EZH2, induces robust cell viability inhibition in DLBCL and other subtypes of lymphomas, displays promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells.
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YM281 is potent, EPZ6438-based, von Hippel-Lindau (VHL)-recruiting PROTAC degrader of EZH2, induces robust cell viability inhibition in DLBCL and other subtypes of lymphomas, displays promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells.
| M.Wt | 1018.284 | |
| Formula | C56H71N7O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tu Y, et al. J Med Chem. 2021 Jul 22;64(14):10167-10184.
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