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Chemical Structure : ZNL-02-096
CAS No.: 2414418-49-6
Catalog No.: PC-22382Not For Human Use, Lab Use Only.
ZNL-02-096 is a potent, selective CRBN-dependent Wee1 kinase PROTAC degrader, induces potent and rapid Wee1 degradation, while sparing PLK1.
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| 2 mg | $258 | In stock | |
| 5 mg | $458 | In stock | |
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ZNL-02-096 is a potent, selective CRBN-dependent Wee1 kinase PROTAC degrader, induces potent and rapid Wee1 degradation, while sparing PLK1.
ZNL-02-096 does not degrade IKZF1 or IKZF3.
ZNL-02-096 (100 nM) yielded CRBN-dependent effects on pCDK1 Y15, while high concentrations (1 μM or above) resulted in the combined effects of inhibition and degradation. ZNL-02-096 induces potent degradation of Wee1 in a CRBN- and proteasome-dependent manner, with maximal degradation achieved at 100 nM.
ZNL-02-096 induces DNA damage, apoptosis, and premature mitosis in MOLT4 cells.
ZNL-02-096 induces anti-proliferative effects and synergizes with Olaparib.
| M.Wt | 799.89 | |
| Formula | C42H45N11O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)- |
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1. Zhengnian Li, et al. Cell Chem Biol. 2020 Jan 16;27(1):57-65.e9.
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