ZNL-02-096 is a potent, selective CRBN-dependent Wee1 kinase PROTAC degrader, induces potent and rapid Wee1 degradation, while sparing PLK1.
ZNL-02-096 does not degrade IKZF1 or IKZF3.
ZNL-02-096 (100 nM) yielded CRBN-dependent effects on pCDK1 Y15, while high concentrations (1 μM or above) resulted in the combined effects of inhibition and degradation. ZNL-02-096 induces potent degradation of Wee1 in a CRBN- and proteasome-dependent manner, with maximal degradation achieved at 100 nM.
ZNL-02-096 induces DNA damage, apoptosis, and premature mitosis in MOLT4 cells.
ZNL-02-096 induces anti-proliferative effects and synergizes with Olaparib.
