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Chemical Structure : CG428
Catalog No.: PC-72115Not For Human Use, Lab Use Only.
CG428 (CG-428) is a first-in-class potent and selective TRK degrader (PROTAC) with DC50 of 0.36 nM.
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CG428 (CG-428) is a first-in-class potent and selective TRK degrader (PROTAC) with DC50 of 0.36 nM.
CG428 (CG-428) showed selectivity for the degradation of endogenous TPM3-TRKA over ectopically expressed ATP/GTP binding protein-like 4 (AGBL4)-TRKB or ETS variant transcription factor 6 (ETV6)-TRKC fusion proteins in KM12 cells.
CG428 exhibited higher potency for inhibiting growth of KM12 cells with IC50 of 2.9 nM, compared with the parental TRK kinase inhibitor.
CG428 (CG-428) is a valuable chemical tool compound for investigating the in vivo function of TRK fusion during tumorigenesis
| M.Wt | 814.879 | |
| Formula | C43H43FN10O6 | |
| Appearance | Solid | |
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1. Liqun Chen, et al. J Med Chem. 2020 Dec 10;63(23):14562-14575.
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