Catalog No.: PC-38300Not For Human Use, Lab Use Only.
MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM.
MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM.
MS1943 is highly selective for EZH2 over a wide range of methyltransferases including EZH1, as well as 45 kinases.
MS1943 inhibited TNBC cells that express EZH2 (HCC1187, HCC70, BT549 and HCC1954, GI50s=1.1-4.9 uM), but not EZH2 inhibitors (GSK126, CPI-1205, EPZ6438 and C24).
MS1943 reduces EZH2 levels in cancer cells, suppresses tumor growth in vivo.
