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Chemical Structure : MS1943
CAS No.: 2225938-17-8
Catalog No.: PC-38300Not For Human Use, Lab Use Only.
MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM.
MS1943 is highly selective for EZH2 over a wide range of methyltransferases including EZH1, as well as 45 kinases.
MS1943 inhibited TNBC cells that express EZH2 (HCC1187, HCC70, BT549 and HCC1954, GI50s=1.1-4.9 uM), but not EZH2 inhibitors (GSK126, CPI-1205, EPZ6438 and C24).
MS1943 reduces EZH2 levels in cancer cells, suppresses tumor growth in vivo.
| M.Wt | 718.95 | |
| Formula | C42H54N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
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| Chemical Name/SMILES |
6-(6-(4-(2-(2-((3r,5r,7r)-adamantan-1-yl)acetamido)ethyl)piperazin-1-yl)pyridin-3-yl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-indazole-4-carboxamide |
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1. Anqi Ma, et al. Nat Chem Biol. 2020 Feb;16(2):214-222.
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