Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SHP2 PROTAC R1-5C
Catalog No.: PC-38182Not For Human Use, Lab Use Only.
SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50.
SHP2 PROTAC R1-5C is highly selective for SHP2, induces degradation of SHP2 in leukemic cells at submicromolar concentrations.
SHP2 PROTAC R1-5C inhibits MAPK signaling, and suppresses cancer cell growth.
SHP2 PROTACs serve as an alternative strategy for targeting ERK-dependent cancers and are useful tools alongside allosteric inhibitors for dissecting the mechanisms by which SHP2 exerts its oncogenic activity.
| M.Wt | 1119.057 | |
| Formula | C52H69Cl2N7O16 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Vidyasiri Vemulapalli, et al. Biochemistry. 2021 Aug 31;60(34):2593-2609.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
