Chemical Structure : SD-91
CAS No.:
2497583-03-4
SD-91
Catalog No.: PC-24975Not For Human Use, Lab Use Only.
SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line.
SD-91 binds to STAT3 protein with a high affinity and displays >300-fold selectivity over other STAT family protein members.
SD-91 potently and effectively induces degradation of STAT3 protein and displays a high selectivity over other STAT members and >7000 non-STAT proteins in cells.
SD-91 selectively depletes STAT3 protein in tumor tissues with a persistent effect. complete and long-lasting tumor regression in the MOLM-16 xenograft model in mice.
Physicochemical Properties
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M.Wt
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Formula
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C59H62N9O13P
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-ynoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indole-5-carbonyl)phosphonic acid
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References
1. Zhou H, et al. ACS Med Chem Lett. 2021 May 10;12(6):996-1004.
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