SD-91 is a potent, selective STAT3 PROTAC degrader with DC50 of 17 nM in SU-DHL-1 cell line.
SD-91 binds to STAT3 protein with a high affinity and displays >300-fold selectivity over other STAT family protein members.
SD-91 potently and effectively induces degradation of STAT3 protein and displays a high selectivity over other STAT members and >7000 non-STAT proteins in cells.
SD-91 selectively depletes STAT3 protein in tumor tissues with a persistent effect. complete and long-lasting tumor regression in the MOLM-16 xenograft model in mice.
