Chemical Structure : G6374
CAS No.:
G6374
(G-6374)
Catalog No.: PC-25906Not For Human Use, Lab Use Only.
G6374 is a selective, effective PROTAC degrader for endogenous IRE1 with DC50 of 0.04 uM and Dmax of 93% in AMO1 multiple myeloma (MM) cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
G6374 is a selective, effective PROTAC degrader for endogenous IRE1 with DC50 of 0.04 uM and Dmax of 93% in AMO1 multiple myeloma (MM) cells.
G6374 induced effective depletion of IRE1 in KMS27 MM cells, which express similarly high IRE1 levels, with a Dmax of 98% and a DC50 of 0.13 μM.
G6374 promotes stable association between IRE1 and VHL, and drives IRE1 degradation.
G6374 selectively inhibits IRE1-dependent cancer-cell proliferation regardless of the underlying dependency mode.
Physicochemical Properties
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M.Wt
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883.17
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Formula
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C47H66N10O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R)-4-hydroxy-1-((S)-2-(5-(4-((1r,4S)-4-((8-isopropyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)piperazin-1-yl)pentanamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
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References
1. Du J, et al. Nat Commun. 2025 Dec 11. doi: 10.1038/s41467-025-66382-8.
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