Chemical Structure : PDCD2 degrader 10e
CAS No.:
PDCD2 degrader 10e
Catalog No.: PC-21116Not For Human Use, Lab Use Only.
PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.
PDCD2 degrader 10e induces a concentration-dependent G2/M phase arrest, effectively inhibits the cell cycle progression in MOLT-4 cells.
PDCD2 degrader 10e displays a significant reduction of PDCD2 in MOLT-4 cells, but does not significantly impede cell viability.
PDCD2 degrader 10e is a pharmacological probe, we demonstrate that PDCD2 functions as a critical regulator of cell growth by modulating the progression of the cell cycle in T lymphoblasts.
Programmed cell death 2 (PDCD2) is a member of the B-cell lymphoma 2 (Bcl-2) family of proteins, which are critical regulators of apoptosis.
Physicochemical Properties
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M.Wt
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832.84
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Formula
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C45H39F3N6O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((1S)-1-(6-((1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4- yl)oxy)acetyl)piperidin-4-yl)amino)pyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2- naphthamide
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References
1. Wenzhi Ji, et al. Angew Chem Int Ed Engl. 2023 Sep 1;e202308292.
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