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Chemical Structure : PDCD2 degrader 10e
Catalog No.: PC-21116Not For Human Use, Lab Use Only.
PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.
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PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.
PDCD2 degrader 10e induces a concentration-dependent G2/M phase arrest, effectively inhibits the cell cycle progression in MOLT-4 cells.
PDCD2 degrader 10e displays a significant reduction of PDCD2 in MOLT-4 cells, but does not significantly impede cell viability.
PDCD2 degrader 10e is a pharmacological probe, we demonstrate that PDCD2 functions as a critical regulator of cell growth by modulating the progression of the cell cycle in T lymphoblasts.
Programmed cell death 2 (PDCD2) is a member of the B-cell lymphoma 2 (Bcl-2) family of proteins, which are critical regulators of apoptosis.
| M.Wt | 832.84 | |
| Formula | C45H39F3N6O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wenzhi Ji, et al. Angew Chem Int Ed Engl. 2023 Sep 1;e202308292.
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