Catalog No.: PC-21116Not For Human Use, Lab Use Only.
PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.
PDCD2 degrader 10e is a first-in-class small molecule degrader of programmed cell death 2 (PDCD2), induces PDCD2 degradation in a dose-dependent manner with DC50 value of 2 nM (MOLT-4 cells, 24 h, Emax=96.7%), shows highproteome-wide selectivity.
PDCD2 degrader 10e induces a concentration-dependent G2/M phase arrest, effectively inhibits the cell cycle progression in MOLT-4 cells.
PDCD2 degrader 10e displays a significant reduction of PDCD2 in MOLT-4 cells, but does not significantly impede cell viability.
PDCD2 degrader 10e is a pharmacological probe, we demonstrate that PDCD2 functions as a critical regulator of cell growth by modulating the progression of the cell cycle in T lymphoblasts.
Programmed cell death 2 (PDCD2) is a member of the B-cell lymphoma 2 (Bcl-2) family of proteins, which are critical regulators of apoptosis.
