Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : HDAC3 PROTAC P7
Catalog No.: PC-21118Not For Human Use, Lab Use Only.
HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%).
HDAC3 PROTAC P7 not demonstrate a significant effect on the levels of HDAC1, HDAC2 and HDAC6, while significant effects on HDAC4 at >3.3 uM.
HDAC3 PROTAC P7 is a potent and selective HDAC3 PROTACthat can also trigger HDAC8 degradation at higher concentrations.
HDAC3 PROTAC P7 shows anti-inflammatory activityin THP-1 derivedM1-like macrophage, decreases the secretion of pro-inflammatory cytokines in M1-like macrophages derived from human primary macrophages.
| M.Wt | 832.12 | |
| Formula | C45H65N7O6S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Chunlong Zhao, et al. Angew Chem Int Ed Engl. 2023 Aug 28;e202310059.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
