dCBP-1 | p300/CBP PROTAC | Probechem Biochemicals

Chemical Structure : dCBP-1

CAS No.: 2484739-25-3

dCBP-1 (p300/CBP PROTAC)

Catalog No.: PC-38019Not For Human Use, Lab Use Only.

dCBP-1 is a potent, selective chemical degrader of p300/CBP based on PROTAC.

Packing	Price	Stock
5 mg	$198	In stock
10 mg	$328	In stock
25 mg	$558	In stock
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Biological Activity

dCBP-1 is a potent, selective chemical degrader of p300/CBP based on PROTAC.
dCBP-1 induces degradation of large proteins, including BCR-ABL and SMARCA2/4.
dCBP-1 also decreases IKZF1 and IKZF3 levels by direct degradation or transcription effects.
dCBP-1 induces near-complete p300/CBP degradation across other multiple myeloma cell lines.
dCBP-1 is a high-quality selective chemical inhibitor of p300/CBP function.

Physicochemical Properties

M.Wt	1028.13
Formula	C51H63F2N11O10
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1Hpyrazol-4-yl)-1(2H)-quinolinyl]-1-[1-[15-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-4-piperidinyl]-1,4,6,7-tetrahydro-N-methyl-

References

1. Vannam R, et al. Cell Chem Biol. 2021 Apr 15;28(4):503-514.e12.