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Chemical Structure : BI-3663
CAS No.: 2341740-84-7
Catalog No.: PC-36067Not For Human Use, Lab Use Only.
BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $278 | In stock | |
| 5 mg | $478 | In stock | |
| 10 mg | $788 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote |
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BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines.
BI-3663 degraded PTK2 potently (DC50 = 27 nM) with a maximally obtainable degradation at the chosen experimental conditions of 95% (Dmax) in human lung adenocarcinoma cell line A549 after 16 hours treatment.
BI-3663 does not phenocopy the reported antiproliferative effects of PTK2 depletion in any of the cell lines tested.
| M.Wt | 917.84 | |
| Formula | C44H42F3N7O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3-oxopropoxy)ethoxy)ethoxy)ethyl)-3-methoxy-4-((4-((3-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide |
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1. Popow J, et al. J Med Chem. 2019 Feb 9. doi: 10.1021/acs.jmedchem.8b01826.
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