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HLB-0532259

Chemical Structure : HLB-0532259

CAS No.: 2566733-45-5

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HLB-0532259 (HLB0532259)

Catalog No.: PC-23772Not For Human Use, Lab Use Only.

HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells.
    HLB-0532259 degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM, respectively.
    HLB-0532259 promotes the degradation of Aurora-A, which elicits concomitant N-Myc degradation, with nanomolar potency and excellent selectivity.

    Physicochemical Properties

    M.Wt 748.84
    Formula C40H44N8O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-cyclopentyl-2-((4-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

    References

    1. Tang J, et al. Cell Chem Biol. 2025 Jan 6:S2451-9456(24)00516-6.

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