Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MDEG-541
CAS No.:
Catalog No.: PC-23408Not For Human Use, Lab Use Only.
MDEG-541 is a small molecule MYC PROTAC degrader, induces cereblon-dependent degradation of MYC, GSPT1/2, and PLK1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $238 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MDEG-541 is a small molecule MYC PROTAC degrader, induces cereblon-dependent degradation of MYC, GSPT1/2, and PLK1.
MDEG-541 is based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide.
MDEG-541 regulates MYC in a fashion dependent on CRBN, ubiquitination, and the proteasome, the compound acts pleiotropic and also decreased the expression of G1 To S Phase Transition 1 (GSPT1), GSPT2, and the Polo-like kinase 1 (PLK1).
MDEG-541 shows cellular activity in conventional gastrointestinal cancer cell lines and primary cancer organoids.
| M.Wt | 674.83 | |
| Formula | C35H38N4O6S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(Z)-2-(2,6-dioxopiperidin-3-yl)-N-(8-(5-(4-isopropylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)octyl)-1,3-dioxoisoindoline-5-carboxamide |
|
1. Lier S, et al. Bioorg Chem. 2022 Feb;119:105505.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
