Chemical Structure : CQ627
CAS No.:
CQ627
(CQ-627)
Catalog No.: PC-23702Not For Human Use, Lab Use Only.
CQ627 is the first right open reading frame kinase 2 (RIOK2) molecular glue degrader with DC50 value of 410 nM and Dmax of 83.4% in MOLT4 leukemia cell line via UPS by recruiting E3 ubiquitin ligase RNF126.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CQ627 is the first right open reading frame kinase 2 (RIOK2) molecular glue degrader with DC50 value of 410 nM and Dmax of 83.4% in MOLT4 leukemia cell line via UPS by recruiting E3 ubiquitin ligase RNF126.
CQ627 (1 uM) significantly down-regulated RIOK2 protein level at 12 h, with a maximum degradation of 94.8 % at 24 h.
CQ627 dose-dependently induces apoptosis and blocks cell cycles in G2/M phase in MOLT4 leukemia cells.
CQ627 suppresses ATPase activity (IC50=98.42 nM) and downstream signal of RIOK2. CQ627 induces MOLT-4 cell cycle arrest and apoptosis.
CQ627 displays potent antiproliferative activity in various tumor cells, with superior activity (IC50 < 0.35 μM) in MOLT-4, HL-60 and OCILY3 cell lines.
CQ627 (10 mg/kg, i.p.) inhibits tumor growth in the MOLT-4 tumor xenografted model.
Physicochemical Properties
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M.Wt
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697.65
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Formula
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C36H27F4N7O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-1-(4-fluorophenyl)-4-(4-(4-(8-(6-methoxypyridin-3-yl)-4-oxo-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]quinolin-1-yl)-2-(trifluoromethyl)phenyl)piperazin-1-yl)but-2-ene-1,4-dione
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References
1. Ma H, et al. Eur J Med Chem. 2024 Dec 15;283:117166.
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