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dTAGV-1

Chemical Structure : dTAGV-1

CAS No.: 2451573-86-5

dTAGV-1

Catalog No.: PC-27715Not For Human Use, Lab Use Only.

dTAGV-1 is a selective FKBP12F36V PORTAC degrader, induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduces proliferative capacity of cancer cells, and decreases levels of target proteins.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

dTAGV-1 is a selective FKBP12F36V PORTAC degrader, induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduces proliferative capacity of cancer cells, and decreases levels of target proteins.

Physicochemical Properties

M.Wt 1247.56
Formula C68H90N6O14S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

References

1. Dezhi Li, et al. J Clin Invest. 2024 Dec 24:e174249.

2. Nabet B, et al. Nat Commun. 2020 Sep 18;11(1):4687.

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