Chemical Structure : dTAGV-1
CAS No.: 2451573-86-5
Catalog No.: PC-27715Not For Human Use, Lab Use Only.
dTAGV-1 is a selective FKBP12F36V PORTAC degrader, induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduces proliferative capacity of cancer cells, and decreases levels of target proteins.
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dTAGV-1 is a selective FKBP12F36V PORTAC degrader, induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduces proliferative capacity of cancer cells, and decreases levels of target proteins.
| M.Wt | 1247.56 | |
| Formula | C68H90N6O14S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate |
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1. Dezhi Li, et al. J Clin Invest. 2024 Dec 24:e174249.
2. Nabet B, et al. Nat Commun. 2020 Sep 18;11(1):4687.

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