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Chemical Structure : ARD-69
Catalog No.: PC-49044Not For Human Use, Lab Use Only.
ARD-69 is a highly potent PROTAC degrader of androgen receptor (AR), effectively induces degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1 with DC50 values of 0.86, 0.76, and 10.4 nM, respectively.
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ARD-69 is a highly potent PROTAC degrader of androgen receptor (AR), effectively induces degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1 with DC50 values of 0.86, 0.76, and 10.4 nM, respectively.
ARD-69 is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression.
ARD-69 potently inhibits cell growth in AR-positive prostate cancer cell lines and is >100 times more potent than AR antagonists.
ARD-69 effectively reduces the level of AR protein in xenograft tumor tissue in mice.
| M.Wt | 1129.82 | |
| Formula | C62H74ClFN8O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xin Han, et al. J Med Chem. 2019 Jan 24;62(2):941-964.
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