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Chemical Structure : MD-224
CAS No.: 2136247-12-4
Catalog No.: PC-49045Not For Human Use, Lab Use Only.
MD-224 is a small-molecule MDM2 degrader based on the proteolysis targeting chimera (PROTAC), effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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MD-224 is a small-molecule MDM2 degrader based on the proteolysis targeting chimera (PROTAC), effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells.
MD-224 inhibits growth of RS4;11 cells with IC50 of 1.5 nM and low nanomolar IC50 values in a panel of leukemia cell lines.
MD-224 achieves complete and durable tumor regression in vivo in the RS4;11 xenograft tumor model in mice at well-tolerated dose schedules.
| M.Wt | 889.806 | |
| Formula | C48H43Cl2FN6O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide |
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1. Yangbing Li, et al. J Med Chem. 2019 Jan 24;62(2):448-466.
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