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Chemical Structure : TMX-4153
Catalog No.: PC-20167Not For Human Use, Lab Use Only.
TMX-4153 (TMX4153) is a bivalent PIP4K2C degrader (MOLT4 cells, DC50=24 nM, Dmax=921% at 1 uM) based on TMX-4084, rapidly and selectively degrades endogenous PIP4K2C.
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TMX-4153 (TMX4153) is a bivalent PIP4K2C degrader (MOLT4 cells, DC50=24 nM, Dmax=921% at 1 uM) based on TMX-4084, rapidly and selectively degrades endogenous PIP4K2C.
TMX-4153 exhibits retained potency as the related parental compound (TMX-4084) for PIP4K2C with KD of 42 nM.
TMX-4153 showes exclusive proteome-wide degradation selectivity for PIP4K2C in MOLT4 cells (treatment for 5 h at 1 uM).
TMX-4153 is a tool compounds to interrogate the biological function and therapeutic potential of PIP4K2C.
| M.Wt | 1079.76 | |
| Formula | C59H67ClN10O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Teng M, et al. Angew Chem Int Ed Engl. 2023 Mar 10:e202302364.
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