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Chemical Structure : KT-474
CAS No.: 2432994-31-3
Catalog No.: PC-20693Not For Human Use, Lab Use Only.
KT-474 (SAR444656, KYM-001) is a potent, selective, and orally bioavailable heterobifunctional IRAK4 PROTAC degrader with DC50 of 2 nM in OCI-Ly10 cells, IC50 of 41 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $128 | In stock | |
| 5 mg | $218 | In stock | |
| 10 mg | $348 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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| M.Wt | 865.94 | |
| Formula | C44H49F2N11O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-((S)-2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide |
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1. Ackerman L, et al. Nat Med. 2023 Dec;29(12):3127-3136.
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