MGD-28

Chemical Structure : MGD-28

CAS No.: 2991818-13-2

Catalog No.: PC-26524Not For Human Use, Lab Use Only.

MGD-28 is a potent, orally active CRBN-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), also degrades CK1α (DC50=7.8 nM).

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
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100 mg		Get quote

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Biological Activity

MGD-28 is a potent, orally active CRBN-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), also degrades CK1α (DC50=7.8 nM).

Physicochemical Properties

M.Wt	595.68
Formula	C33H34FN7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(4-(((2-(2,6-Dioxopiperidin-3-yl)-3-methyl-1-oxo-1,2,3,4-tetrahydrophthalazin-5-yl)amino)methyl)benzyl)piperazin-1-yl)-2-fluorobenzonitrile

References

1. Pengyun Li, et al. J Hematol Oncol. 2024 Sep 2;17(1):77.

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MGD-28

Biological Activity

Physicochemical Properties

References

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