TKP-5

Chemical Structure : TKP-5

Catalog No.: PC-26534Not For Human Use, Lab Use Only.

TKP-5 is a highly potent BRD4 PROTAC degrader with DC50 of 16.78 nM in mouse keratinocyte cell line KCMH-1, Kd of 150 nM for BRD4-BD1, exhibits inhibitory activity against TSLP expression.

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Biological Activity

TKP-5 is a highly potent BRD4 PROTAC degrader with DC50 of 16.78 nM in mouse keratinocyte cell line KCMH-1, Kd of 150 nM for BRD4-BD1, exhibits inhibitory activity against TSLP expression.

Physicochemical Properties

M.Wt	833.90
Formula	C44H47N7O10
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-6-(4-((4-(3-(2-(2-Acetamidoethyl)-5-ethoxy-4-methoxyphenyl)-3-oxoprop-1-en-1-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)hexanamide

References

1. Hiroyuki Yamakoshi, et al. J Med Chem. 2026 Apr 9;69(7):8388-8416.

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TKP-5

Biological Activity

Physicochemical Properties

References

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