M4K3233

Chemical Structure : M4K3233

Catalog No.: PC-26691Not For Human Use, Lab Use Only.

M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.3 in HEK-293 cells, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway.

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Biological Activity

M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.3 in HEK-293 cells, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway.

Physicochemical Properties

M.Wt	772.90
Formula	C44H48N6O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-Dioxo-3-piperidyl)-5-[4-[[4-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridyl]phenyl]piperazin-1-yl]methyl]-1-piperidyl]isoindoline-1,3-dione

References

1. Daniel T Webb, et al. J Med Chem. 2026 May 3. doi: 10.1021/acs.jmedchem.6c00714.

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M4K3233

Biological Activity

Physicochemical Properties

References

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