M4K3250

Chemical Structure : M4K3250

Catalog No.: PC-26692Not For Human Use, Lab Use Only.

M4K3233 is a potent, selective first-in-class ALK2 degrader with pDC50 of 7.9 in HEK-293 cells and Dmax=78%, induces ALK2 degradation via a CRBN-mediated, ubiquitin, proteasome/lysosome combinatorial pathway.

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Biological Activity

Physicochemical Properties

M.Wt	760.87
Formula	C43H45FN6O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-Dioxopiperidin-3-yl)-5-(4-((4-(4-(5-(4-fluoro-3,5-dimethoxyphenyl)-4-methylpyridin-3-yl)phenyl)piperazin-1-yl)methyl)piperidin-1-yl)isoindoline-1,3-dione

References

1. Daniel T Webb, et al. J Med Chem. 2026 May 3. doi: 10.1021/acs.jmedchem.6c00714.

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M4K3250

Biological Activity

Physicochemical Properties

References

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