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Chemical Structure : TD-802
Catalog No.: PC-21127Not For Human Use, Lab Use Only.
TD-802 is potent, cereblon-mediated androgen receptor PROTAC degrader, effectively inducs AR protein degradation with DC50 of 12.5 nM and Emax 93% in LNCaP prostate cancer cells.
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TD-802 is potent, cereblon-mediated androgen receptor PROTAC degrader, effectively inducs AR protein degradation with DC50 of 12.5 nM and Emax 93% in LNCaP prostate cancer cells.
TD-802 potently inhibits LNCaP and VCaP cell proliferation with IC50 of 98 and 44 nM, respectively.
TD-802 (30 mg/kg, 20% PEG400 + 3% Tween 80 in PBS, i.p., once a day for 10 days) effectively inhibited the growth of AR-positive VCaP prostate in vivo, with no additional loss in body weight or off-target effects.
| M.Wt | 957.57 | |
| Formula | C52H61ClN10O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Akshay D Takwale, et al. Eur J Med Chem. 2020 Dec 15;208:112769.
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