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Chemical Structure : KYH1872
Catalog No.: PC-21045Not For Human Use, Lab Use Only.
KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker.
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KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker.
KYH1872 induces the degradation of NEK9, FAK, CDK4, CDK6, and WEE1 in cells treated with 1 and 10 μM compound for 24 h.
KYH1872 binds to the KLHDC2 protein with Kd of <2 nM.
| M.Wt | 1248.50 | |
| Formula | C57H77N13O13S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Younghoon Kim, et al. Cell Chem Biol. 2023 Aug 5;S2451-9456(23)00236-2.
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