KYH1872 | PROTAC | Probechem Biochemicals

Chemical Structure : KYH1872

KYH1872 (KYH 1872, KYH-1872)

Catalog No.: PC-21045Not For Human Use, Lab Use Only.

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Biological Activity

KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker.
KYH1872 induces the degradation of NEK9, FAK, CDK4, CDK6, and WEE1 in cells treated with 1 and 10 μM compound for 24 h.
KYH1872 binds to the KLHDC2 protein with Kd of <2 nM.

Physicochemical Properties

M.Wt	1248.50
Formula	C57H77N13O13S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. Younghoon Kim, et al. Cell Chem Biol. 2023 Aug 5;S2451-9456(23)00236-2.

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KYH1872 (KYH 1872, KYH-1872)

Biological Activity

Physicochemical Properties

References

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