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Chemical Structure : ARD-2128
Catalog No.: PC-21126Not For Human Use, Lab Use Only.
ARD-2128 is a potent, orally active PROTAC androgen receptor (AR) degrader with DC50 of 0.28 nM in CcaP cell line.
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ARD-2128 is a potent, orally active PROTAC androgen receptor (AR) degrader with DC50 of 0.28 nM in CcaP cell line.
ARD-2128 potently inhibits cell growth in the LNCaP cell line with IC50 of 5 nM.
ARD-2128 effectively suppresses the expression of PSA and TMPRSS2 genes in both VCaP and LNCaP cell lines in a dose-dependent manner, ARD-2128 is effective in reducing the mRNA levels of PSA and TMPRSS2 genes at 10 nM.
ARD-2128 (10-40 mg/kg, oral) exhibits antitumor efficacy in the VCaP xenograft tumor model in SCID mice.
| M.Wt | 820.39 | |
| Formula | C45H50ClN7O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xin Han, et al. J Med Chem. 2021 Sep 9;64(17):12831-12854.
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