U7D-1 | USP7 PROTAC | Probechem Biochemicals

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Chemical Structure : U7D-1

CAS No.:

U7D-1 (USP7 PROTAC U7D-1)

Catalog No.: PC-38903Not For Human Use, Lab Use Only.

U7D-1 is a selective USP7-degrading Proteolysis Targeting Chimera (PROTAC) with DC50 of 33 nM in RS4;11 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

U7D-1 is a selective USP7-degrading Proteolysis Targeting Chimera (PROTAC) with DC50 of 33 nM in RS4;11 cells.
U7D-1 showed selective and effective USP7 degradation, and maintained potent cell growth inhibition in p53 mutant cancer cells.

Physicochemical Properties

M.Wt	940.159
Formula	C53H65N9O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dioxopiperidin-3-yl)-4-((11-((4-(6-((4-hydroxy-1-((R)-3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-3-yl)benzyl)amino)undecyl)amino)isoindoline-1,3-dione

References

1. Yuan Pei, et al. Angew Chem Int Ed Engl. 2022 Jun 12. doi: 10.1002/anie.202204395.

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U7D-1 (USP7 PROTAC U7D-1)

Biological Activity

Physicochemical Properties

References

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