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Chemical Structure : U7D-1
CAS No.:
Catalog No.: PC-38903Not For Human Use, Lab Use Only.
U7D-1 is a selective USP7-degrading Proteolysis Targeting Chimera (PROTAC) with DC50 of 33 nM in RS4;11 cells.
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U7D-1 is a selective USP7-degrading Proteolysis Targeting Chimera (PROTAC) with DC50 of 33 nM in RS4;11 cells.
U7D-1 showed selective and effective USP7 degradation, and maintained potent cell growth inhibition in p53 mutant cancer cells.
| M.Wt | 940.159 | |
| Formula | C53H65N9O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2,6-dioxopiperidin-3-yl)-4-((11-((4-(6-((4-hydroxy-1-((R)-3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-3-yl)benzyl)amino)undecyl)amino)isoindoline-1,3-dione |
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1. Yuan Pei, et al. Angew Chem Int Ed Engl. 2022 Jun 12. doi: 10.1002/anie.202204395.
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