Catalog No.: PC-47017Not For Human Use, Lab Use Only.
SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively.
SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively.
SJ6986 displays selectivity over classical IMiD neosubstrates, such as IKZF1/3.
SJ6986 is a valuable chemical probe for studying the role of GSPT1/2 in vitro and in vivo.
