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Chemical Structure : SJ6986
CAS No.: 2765625-93-0
Catalog No.: PC-47017Not For Human Use, Lab Use Only.
SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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SJ6986 is a potent, selective, and orally bioavailable small-molecule GSPT1/2 degrader with DC50 of 2.1 nM (GSPT1), demonstrates antiproliferative activities in leukemia cell lines MV4-11 and MHH-CALL-4 with EC50 of 1.5 and 0.4 nM, respectively.
SJ6986 displays selectivity over classical IMiD neosubstrates, such as IKZF1/3.
SJ6986 is a valuable chemical probe for studying the role of GSPT1/2 in vitro and in vivo.
| M.Wt | 497.401 | |
| Formula | C20H14F3N3O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide |
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1. Gisele Nishiguchi, et al. J Med Chem. 2021 Jun 10;64(11):7296-7311.
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