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Chemical Structure : JCS-1
Catalog No.: PC-47084Not For Human Use, Lab Use Only.
JCS-1 is a RG3039-based degarder (PROTAC) of the RNA decapping scavenger protein DcpS exhibiting effective degradation of DcpS at nanomolar concentrations, non-covalently binds DcpS and recruits the E3 ligase VHL, induces potent, rapid, and sustained DcpS degradation in AML cell lines.
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JCS-1 is a RG3039-based degarder (PROTAC) of the RNA decapping scavenger protein DcpS exhibiting effective degradation of DcpS at nanomolar concentrations, non-covalently binds DcpS and recruits the E3 ligase VHL, induces potent, rapid, and sustained DcpS degradation in AML cell lines.
| M.Wt | 1174.425 | |
| Formula | C62H79N9O12S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jake C Swartzel, et al. ACS Chem Biol. 2022 Jun 24. doi: 10.1021/acschembio.2c00145.
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