ZXH-1-161

Chemical Structure : ZXH-1-161

CAS No.: 2407654-51-5

Catalog No.: PC-47018Not For Human Use, Lab Use Only.

ZXH-1-161 is a potent, selective small-molecule GSPT1 degrader, inhibits ceell viability in MM1.S with IC50 of 39 nM.

Packing	Price	Stock
5 mg	$218	In stock
10 mg	$358	In stock
25 mg	$598	In stock
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Biological Activity

ZXH-1-161 is a potent, selective small-molecule GSPT1 degrader, inhibits ceell viability in MM1.S with IC50 of 39 nM.

ZXH-1-161 is a superior tool to CC-885 for exploring the therapeutic potential of GSPT1 degradation and may provide additional opportunities for therapeutically targeting GSPT1.

Physicochemical Properties

M.Wt	468.52
Formula	C26H24N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-((2-((2,3-dihydro-1H-inden-5-yl)amino)pyrimidin-4-yl)amino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Chelsea E Powell, et al. ACS Chem Biol. 2020 Oct 16;15(10):2722-2730.

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ZXH-1-161

Biological Activity

Physicochemical Properties

References

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