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ZXH-1-161

Chemical Structure : ZXH-1-161

CAS No.: 2407654-51-5

ZXH-1-161

Catalog No.: PC-47018Not For Human Use, Lab Use Only.

ZXH-1-161 is a potent, selective small-molecule GSPT1 degrader, inhibits ceell viability in MM1.S with IC50 of 39 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZXH-1-161 is a potent, selective small-molecule GSPT1 degrader, inhibits ceell viability in MM1.S with IC50 of 39 nM.
ZXH-1-161 is a superior tool to CC-885 for exploring the therapeutic potential of GSPT1 degradation and may provide additional opportunities for therapeutically targeting GSPT1.

Physicochemical Properties

M.Wt 468.52
Formula C26H24N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(4-((2-((2,3-dihydro-1H-inden-5-yl)amino)pyrimidin-4-yl)amino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

References

1. Chelsea E Powell, et al. ACS Chem Biol. 2020 Oct 16;15(10):2722-2730.

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