Chemical Structure : MS115
CAS No.:
MS115
Catalog No.: PC-24376Not For Human Use, Lab Use Only.
MS115 is a potent, selective best-in-class PRMT5 PROTAC degrader, induces rapid and robust degradation of PRMT5 (DC50=17.4 nM) and its binding partner MEP50 (DC50=11.3 nM, MDAMB468 cells), in a time-, concentration-, VHL- and UPS-dependent manner.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MS115 is a potent, selective best-in-class PRMT5 PROTAC degrader, induces rapid and robust degradation of PRMT5 (DC50=17.4 nM) and its binding partner MEP50 (DC50=11.3 nM, MDAMB468 cells), in a time-, concentration-, VHL- and UPS-dependent manner.
MS115 achieves greater than 85% degradation of both PRMT5 and MEP50.
MS115 is significantly more potent in degrading the PRMT5/MEP50 complex than the cereblon-recruiting YZ-836P and MS4322.
MS115 is a highly selective PRMT5/MEP50 complex degrader.
MS115 effectively inhibits the proliferation and clonogenicity of breast cancer cells, potently degrades PRMT5 and MEP50, reduces downstream sDMA, and inhibits proliferation of PC-3 prostate cancer cells.
Physicochemical Properties
|
M.Wt
|
1258.52
|
|
Formula
|
C63H88FN11O13S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-1-((2S,4R)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidin-2-yl)-3-(4-(4-methylthiazol-5-yl)phenyl)-1,5-dioxo-9,12,15,18,21-pentaoxa-2,6-diazatetracosan-24-oyl)piperidin-4-yl)amino)pyrimidine-4-carboxamide
|
References
1. Zhong Y, et al. J Med Chem. 2025 Apr 15. doi: 10.1021/acs.jmedchem.5c00198.
Contact Us
sales@probechem.com
