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DeFer-2

Chemical Structure : DeFer-2

CAS No.:

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DeFer-2

Catalog No.: PC-20653Not For Human Use, Lab Use Only.

DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DeFer-2 is an oleic acid (OA)-based ferritin-targeting PROTAC binding Kd of 17.1 uM, degrades ferritin and rapidly elevates the free iron content, induces pyroptosis.
DeFer-2 caused the caspase 3-GSDME-mediated pyroptosis in cancer cells rather than typical ferroptosis, which is always associated with iron ion overload.
DeFer-2 (tailored albumin-based nano-formulation) substantially inhibited tumor growth and prolonged the survival time of mice bearing B16F10 subcutaneous tumors with negligible adverse effects.

Physicochemical Properties

M.Wt 780.13
Formula C44H69N5O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C([C@H]1N(C([C@@H](NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

References

1. Yu Chen, et al. Journal of the American Chemical Society, April 24, 2023

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