PTD10 | BTK PROTAC | Probechem Biochemicals

Chemical Structure : PTD10

PTD10 (BTK PROTAC PTD10)

Catalog No.: PC-20816Not For Human Use, Lab Use Only.

PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853.

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Biological Activity

PTD10 is a highly potent BTK PROTAC degrader with DC50 of 0.5 nM in TMD8 cells, inhibits cell growth and induces apoptosis more potently than parent molecule GDC-0853.

Physicochemical Properties

M.Wt	922.02
Formula	C49H51N11O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCC(N4C[C@H](C)N(C5=CC=C(NC6=CC(C7=C(CO)C(N8C(C(N9CC8)=CC%10=C9CC(C)(C)C%10)=O)=NC=C7)=CN(C)C6=O)N=C5)CC4)=O)=O

References

1. Yi-Qian Li, et al. J Med Chem. 2023 May 17. doi: 10.1021/acs.jmedchem.3c00176.

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PTD10 (BTK PROTAC PTD10)

Biological Activity

Physicochemical Properties

References

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