FF2049 | HDAC1-3 PROTAC | Probechem Biochemicals

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Chemical Structure : FF2049

FF2049 (FF-2049)

Catalog No.: PC-23853Not For Human Use, Lab Use Only.

FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells.
FF2049 induced strong and selective degradation of HDAC1–3 with no effect on other HDACs.
FF2049 induced degradation via binding to FEM1B and HDAC1 in neddylation-dependent manner.
FF2049 induced a significant increase in early and late apoptotic cells in hematological cancer cell lines MM.1S and MV4–11.

Physicochemical Properties

M.Wt	656.14
Formula	C31H38ClN7O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-(2-{7-[2-Chloro-N-(2-cyanoethyl)acetamido]-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl}acetamido)acetamido]-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

References

1. Feller F, et al. J Med Chem. 2025 Jan 13. doi: 10.1021/acs.jmedchem.4c02569.

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FF2049 (FF-2049)

Biological Activity

Physicochemical Properties

References

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