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SJ44236

Chemical Structure : SJ44236

CAS No.:

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SJ44236 (SJ-44236)

Catalog No.: PC-23841Not For Human Use, Lab Use Only.

SJ44236 is a highly potent, selective and orally bioavailable BET PROTAC with BRD4 DC50 of 0.127 nM in MV4-11 cells, induces pronounced degradation of BRD2, BRD3 and BRD4.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SJ44236 is a highly potent, selective and orally bioavailable BET PROTAC with BRD4 DC50 of 0.127 nM in MV4-11 cells, induces pronounced degradation of BRD2, BRD3 and BRD4.
SJ44236 displays potent antiproliferative effect in MV4–11 and HD-MB03 cell lines.
SJ44236 shows improved pharmacokinetic profile over SJ995973.

Physicochemical Properties

M.Wt 753.36
Formula C40H45ClN8O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-(4-((1-(2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)piperidine-2,6-dione

References

1. Actis M, et al. J Med Chem. 2025 Jan 15. doi: 10.1021/acs.jmedchem.4c02709.

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