Chemical Structure : HDAC6 PROTAC A6
CAS No.:
2785404-76-2
HDAC6 PROTAC A6
Catalog No.: PC-23854Not For Human Use, Lab Use Only.
HDAC6 PROTAC A6 is a potent, selective HDAC6 PROTAC degrader with DC50 of 3.5 nM, Dmax values of over 80% in HL-60 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HDAC6 PROTAC A6 is a potent, selective HDAC6 PROTAC degrader with DC50 of 3.5 nM, Dmax values of over 80% in HL-60 cells.
HDAC6 PROTAC A6 induces dose-dependent α-tubulin hyperacetylation with an EC50 of 0.4 μM in HL-60 cells.
does not affect other HDAC related proteins (HDAC1–11, SIRT1–7, and HDRP), HDAC1/2/3/6/7/10 and SIRT1/2/3/5/6.
HDAC6 PROTAC A6 induces the degradation of HDAC6 occurs via the ternary complex formation and ubiquitin–proteasome pathway.
HDAC6 PROTAC A6 inhibits cell viability of leukemia cell lines with double-digit micromolar potency, also induces apoptosis of MOLM13 cells in a caspase 3/7-dependent fashion through arresting the cells in sub-G1 phase.
Physicochemical Properties
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M.Wt
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734.81
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Formula
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C37H46N6O10
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(8-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octanamido)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide
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References
1. Sinatra L, et al. J Med Chem. 2022 Dec 22;65(24):16860-16878.
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