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AH078

Chemical Structure : AH078

CAS No.:

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AH078 (AH-078)

Catalog No.: PC-23899Not For Human Use, Lab Use Only.

AH078 is a potent, highly selective PROTAC degrader of CK1δ and CK1ε with DC50 of 200 nM (CK1δ) in HEK293 cells, shows excellent selectivity over the highly related CK1α isoform.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AH078 is a potent, highly selective PROTAC degrader of CK1δ and CK1ε with DC50 of 200 nM (CK1δ) in HEK293 cells, shows excellent selectivity over the highly related CK1α isoform.
AH078 induces CK1δ degradation at a relatively low concentration of ∼10 nM.
AH078 exhibits VHL-dependent degradation of CKδ and CK1ε with DC50 values of 200 nM estimated from Western blots.

Physicochemical Properties

M.Wt 963.16
Formula C51H60F2N10O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,4S)-1-((S)-2-(8-(4-Fluoro-4-((4-(5-fluoropyridin-2-yl)-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-imidazol-1-yl)methyl)piperidin-1-yl)-8-oxooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

References

1. Haag A, et al. J Med Chem. 2025 Jan 9;68(1):506-530.

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