RET PROTAC RD-23

Chemical Structure : RET PROTAC RD-23

Catalog No.: PC-23771Not For Human Use, Lab Use Only.

RET PROTAC RD-23 is a potent, selective and orally bioavailable RET PROTAC degrader with DC50 of 5.6 nM, Dmax =92% in BaF3 cells.

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Biological Activity

RET PROTAC RD-23 is a potent, selective and orally bioavailable RET PROTAC degrader with DC50 of 5.6 nM, Dmax =92% in BaF3 cells.

M.Wt	927.08
Formula	C52H54N12O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-(4-(5-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)pent-4-yn-1-yl)piperazin-1-yl)piperidin-1-yl)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile

1. Hualong M, et al. J Med Chem. 2025 Jan 7. doi: 10.1021/acs.jmedchem.4c01889.