AN5777

Chemical Structure : AN5777

Catalog No.: PC-23947Not For Human Use, Lab Use Only.

AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS.

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Biological Activity

AN5777 is a potent GSPT1 degrader, binds recombinant CRBN and induces GSPT1 degradation through the UPS.
AN5777 displaysgood antiproliferative activities against U937 and OCI-AML-2 cell with IC50 of 4.49 uM and 2.64 uM respectively.
AN5777 dose-dependently induces G1 phase arrest and apoptosis.

Physicochemical Properties

M.Wt	319.36
Formula	C19H17N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,8-Dimethyl-3-quinolinecarboxylic acid 2-[(2-hydroxyphenyl)methylene]hydrazide

References

1. Shuqun Zhang, et al. Eur J Med Chem. 2024 Jul 5:273:116524.

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AN5777

Biological Activity

Physicochemical Properties

References

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