Chemical Structure : YX0597
CAS No.:
YX0597
(YX-0597)
Catalog No.: PC-24279Not For Human Use, Lab Use Only.
YX0597 is a potent, selective CDK9 PROTAC degrader, potently inhibits GEAC cell growth, especially in radiation-resistant tumor cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YX0597 is a potent, selective CDK9 PROTAC degrader, potently inhibits GEAC cell growth, especially in radiation-resistant tumor cells.
YX0597 dose-dependently induced rapid and stable CDK9 degradation, in parallel with decreased RNA polymerase II S2 phosphorylation and expression of the CDK9 downstream effector MCl1 in GA0518 and AGS cells.
YX0597 potently inhibits tumor proliferation, metastasis, and targets cancer stem cells.
YX0597 epigenetically induces gene expression by increasing chromatin accessibility.
YX0597 dose-dependently decreased YAP1 and TEAD4, at the protein level.
VT00278, a YAP1/TEAD inhibitor, synergized with XY0597 treatment, significantly attenuating radiation-resistant tumor growth and progression, in vivo.
Physicochemical Properties
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M.Wt
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829.35
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Formula
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C42H49ClN8O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1S,3R)-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)-3-(7-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)heptanamido)cyclohexane-1-carboxamide
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References
1. Zhang YY, et al. bioRxiv [Preprint]. 2025 Feb 27:2025.02.22.639565.
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