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Chemical Structure : UBX-382
Catalog No.: PC-49392Not For Human Use, Lab Use Only.
UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM.
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UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM.
UBX-382 efficiently inhibits MEK and ERK signaling in B-cell lymphoma.
UBX-382 degrades various mutant BTK proteins in vitro and in vivo, UBX-382 significantly inhibits cell proliferation in cell lines including C481S mutant.
UBX-382 inhibits hematological cell line proliferation via CRBN dependency.
| M.Wt | 752.880 | |
| Formula | C42H44N10O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ye Seul Lim, et al. Blood Adv. 2022 Oct 21;bloodadvances.2022008121.
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