Catalog No.: PC-49392Not For Human Use, Lab Use Only.
UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM.
UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM.
UBX-382 efficiently inhibits MEK and ERK signaling in B-cell lymphoma.
UBX-382 degrades various mutant BTK proteins in vitro and in vivo, UBX-382 significantly inhibits cell proliferation in cell lines including C481S mutant.
UBX-382 inhibits hematological cell line proliferation via CRBN dependency.
