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Chemical Structure : INY-06-061
Catalog No.: PC-49380Not For Human Use, Lab Use Only.
INY-06-061 is a potent and selective heterobifunctional degrader of ERK5 with binding Kd of 12 nM and DC50 of 21 nM in MOLT4 cells (5h treatment).
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INY-06-061 is a potent and selective heterobifunctional degrader of ERK5 with binding Kd of 12 nM and DC50 of 21 nM in MOLT4 cells (5h treatment).
INY-06-061 displays a similar selectivity profile to both the parental inhibitor INY-06-086 and the original ERK5 inhibitor BAY-885.
INY-06-061-induced ERK5 degradation is dependent on the ubiquitin-proteasome system.
INY-06-061 treatment does not compromise viability in multiple cancer cell lines, does not affect pro-inflammatory cytokine secretion in endothelial cells.
| M.Wt | 1041.249 | |
| Formula | C54H67F3N10O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Inchul You, et al. Cell Chem Biol. 2022 Oct 6;S2451-9456(22)00352-X.
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