Chemical Structure : SK-3-91
CAS No.:
2769753-23-1
SK-3-91
Catalog No.: PC-27299Not For Human Use, Lab Use Only.
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases), induces protein (YTHDF2, e.g.) degradation through the ubiquitin biotinylation (E-STUB) pathway, degrades YTHDF2 and inhibits cell proliferation and induces morphological changes.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases), induces protein (YTHDF2, e.g.) degradation through the ubiquitin biotinylation (E-STUB) pathway, degrades YTHDF2 and inhibits cell proliferation and induces morphological changes.
Physicochemical Properties
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M.Wt
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887.41
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Formula
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C42H47ClN10O8S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(2-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
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References
1. Donovan KA, et al. Cell. 2020 Dec 10;183(6):1714-1731.e10.
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